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Yuri Bunimovich M.D., Ph.D.

  • Associate Professor, Department of Dermatology
  • Associate Professor, Department of Immunology

    Education & Training

  • BSc, Biomedical Engineering, Cornell University, 2000
  • PhD, Chemistry and Chemical Engineering, California Institute of Technology, 2007
  • MD, University of California Los Angeles; Jacobs School of Medicine, SUNY, 2009
  • Post Doctoral Fellowship, NanoSystems Institute, Crump Institute for Molecular Imaging, University of California Los Angeles, 2012
  • Dermatology Residency, University of Pittsburgh, 2015
Representative Publications

1. Bunimovich YL, Ge G, Beverly KC, Ries RS, Hood L, Heath JR. Electrochemically programmed, spatially selective biofunctionalization of silicon wires. Langmuir. 2004 Nov 23;20(24):10630-8. PMID: 15544395.

2. Beckman R, Beverly K, Boukai A, Bunimovich Y, Choi JW, DeIonno E, Green J, Johnston-Halperin E, Luo Y, Sheriff B, Stoddart JF, Heath JR. Molecular Mechanics and Molecular Electronics. Faraday Discuss. 2006;131:9-22; discussion 91-109. PMID: 16512361.

3.  Jung JY, Wu W, Yu Z, Wang SY, Tong WM, Li Z, Johnston-Halperin E, Green JE, Sheriff BA, Boukai A, Bunimovich Y, Williams RS, Heath JR. Circuit fabrication at 17 nm half-pitch by nanoimprint lithography. Nano Lett. 2006 Mar;6(3):351-4.  PMID: 16522021.  

4. Wang J, Bunimovich YL, Sui G, Savvas S, Wang J, Guo Y, Heath JR, Tseng HR. Electrochemical fabrication of conducting polymer nanowires in an integrated microfluidic system. Chem Commun (Camb). 2006 Aug 7;(29):3075-7. PMID: 16855690.

5. Bunimovich YL, Shin YS, Yeo WS, Amori M, Kwong G, Heath JR. Quantitative real-time measurements of DNA hybridization with alkylated nonoxidized silicon nanowires in electrolyte solution. J Am Chem Soc. 2006 Dec 20;128(50):16323-31. PMID: 17165787

6. Green JE, Choi JW, Boukai A, Bunimovich Y, Johnston-Halperin E, DeIonno E, Luo Y, Sheriff BA, Xu K, Shin YS, Tseng HR, Stoddart JF, Heath JR. A 160-kilobit molecular electronic memory patterned at 10(11) bits per square centimetre. Nature. 2007 Jan 25;445(7126):414-7. PMID: 17251976

7. Wang D, Bunimovich Y, Boukai A, Heath JR. Two-dimensional single-crystal nanowire arrays. Small. 2007 Dec;3(12):2043-7. PMID: 18030671. 

8.  Boukai AI, Bunimovich Y, Tahir-Kheli J, Yu JK, Goddard WA 3rd, Heath JR. Silicon nanowires as efficient thermoelectric materials. Nature. 2008 Jan 10;451(7175):168-71. PMID: 18185583. 

9.  Bunimovich YL, Nair-Gill E, Riedinger M, McCracken MN, Cheng D, McLaughlin J, Radu CG, Witte ON. Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. PLoS One. 2014 Aug 7;9(8):e104125. PMID: 25101980

10. Zhou Y, Shurin GV, Zhong H, Bunimovich YL, Han B, Shurin MR. Schwann cells augment cell spreading and metastasis of lung cancer. Cancer Res. 2018; 78(20):5927-5939. PMID: 30135194.

11. Martyn GV, Shurin GV, Keskinov AA, Bunimovich YL, Shurin MR. Schwann cells shape neuro-immune environs and control cancer progression. Cancer Immunol Immunother. 2019; 68(11):1819-1829. PMID: 30607548

12. Shurin GV, Kruglov O, Ding F, Lin Y, Hao X, Keskinov AA, You Z, Lokshin AE, LaFramboise WA, Falo LD Jr, Shurin MR, Bunimovich YL. Melanoma-induced reprogramming of Schwann cell signaling aids tumor growth. Cancer Research, 2019;79(10):2736-2747. PMID: 30914431.

13. Zhang SH, Shurin GV, Khosravi H, Kazi R, Kruglov O, Shurin MR, Bunimovich YL. Immunomodulation by Schwann cells in disease. Cancer Immunol Immunother. 2020;69(2):245-253. PMID: 31676924.

14. Vats K, Kruglov O, Mizes A, Samovich SN, Amoscato, AA, Tyurin VA, Tyurina YY, Kagan VE, Bunimovich YL. Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure. Redox Biol. 2021 Nov;47:102143. PMID: 34592565.

15. Vats K, Kruglov O, Sahoo B, Soman V, Zhang J, Shurin GV, Chandran UR, Skums P, Shurin MR, Zelikovsky A, Storkus WJ, Bunimovich YL. Sensory nerves impede the formation of tertiary lymphoid structures and development of protective antimelanoma immune responses. Cancer Immunol Res. 2022;10(9):1141-1154. PMID: 35834791.

16. Shurin GV, Vats K, Kruglov O, Bunimovich YL, Shurin MR. Tumor-induced T cell polarization by Schwann cells. Cells 2022;11(22):3541. PMID: 36428970.

17.Tyurina YY, Karpalov AA, Tyurin VA, Shurin G, Amoscato AA, Rajasundaram D, Tian H, Bunimovich YL, Nefedova Y, Herrick WG, Parchment RE, Doroshow JH, Bayir H, Srivastava AK, Kagan VE. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 2023;61:102650. PMID: 36870109.

18. Kruglov O, Vats K, Soman V, Tyurin VA, Tyurina YY, Wang J, Williams L, Zhang J, Donahue Carey C, Jaklitsch E, Chandran UR, Bayir H, Kagan VE, Bunimovich YL. Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production. Oncoimmunology 2023; 12(1):2192098. PMID: 3699820.

19. Samovich SN, Mikulska-Ruminska K, Dar HH, Tyurina YY, Tyurin VA, Souryavong AB, Kapralov AA, Amoscato AA, Beharier O, Karumanchi A, St. Croix CM, Yang X, Holman TR, VanDemark AP, Sadovsky Y, Mallampalli RK, Wenzel SE, Gu W, Bunimovich YL, Bahar I, Kagan VE, Bayir H. Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death. Angew Chem Int Ed Engl 2024;63(9):e202314710.

Please click here for a complete list of publications.

Research Interests
  • Neuro-immune regulation of cancer progression.
  • Re-engineering of anti-tumor immunity for the development and testing of novel cancer immunotherapies.
  • Pathogenesis of lipid redox dysregulation in the inflammatory and autoimmune disorders.
  • Role of ferroptosis in the neoplastic and inflammatory skin diseases.
  • Glial functions in cancer, inflammation, wound healing and neuropathy.